Jacobs, L. E., The Ohio State University, Columbus, OH 43210, USA, jacobs.585@osu.edu
Chin, Y. P., The Ohio State University, Columbus, OH 43210, USA, yo@geology.ohio-state.edu
Fimmen, R. L., The Ohio State University, Columbus, OH 43210, USA,
Mash , H. E., U.S. Environmental Protection Agency, Cincinnati, OH 45268, USA,
Weavers, L. K., The Ohio State University, Columbus, OH 43210, USA,

THE PHOTOLYSIS OF IBUPROFEN MEDIATED BY DISSOLVED ORGANIC MATTER

The photolysis of the nonsteroidal anti-inflammatory drug ibuprofen was studied in water and solutions of fulvic acid isolated from Pony Lake, Antarctica; Suwannee River, GA, USA; and Old Woman Creek, OH, USA. At 10 µM ibuprofen degrades by direct photolysis, but the presence of fulvic acids (6 mgC/L) significantly increases reaction rates. This reaction proceeded even more quickly in solutions at lower and more environmentally relevant ibuprofen concentrations (0.1 µM). Quenching studies suggest that the hydroxyl radical is responsible for some of the degradation because isopropanol was able to reduce the reaction rate by 50%. Liquid chromatography with quadrapole time of flight mass spectrometry and 1H NMR spectroscopy reveal the formation of multiple hydrophobic photo-products, with the dominant byproduct identified as 4-(1-ethanol)-β,β-dimethylstyrene with an -OH attached to the benzene ring as well as isobutylacetophenone. Compared to direct photolysis and the other fulvic acids, the presence of Pony Lake fulvic acid significantly increases the production of the major byproduct. Thus, the photofate of ibuprofen in sunlit waters is affected by its concentration and the composition of dissolved organic matter.

Oral presentation

Presentation is given by student: No
Session #:SS01
Date: Friday, June 13, 2008
Time: 2:30 PM

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